The value of traditional rural landscape and nature protected areas in tourism demand: A study on agritourists' preferences

This study focuses on how traditional rural landscape and proximity to a Natura 2000 Site of Community Importance (SCI) might influence consumers\u2019 choice of an agritourism farm for a weekend stay. Data were collected in Umbria region\u2019s (Italy) agritourism farms in 2014 by interviewing 160 tourists. Results from a discrete choice experiment reveal that the most important feature affecting the interviewees\u2019 propensity to pay a premium price to stay in an agritourism farm is the well-preserved traditional landscape (willingness to pay 32.32\u20ac/night for two people), followed by the availability of a swimming pool (willingness to pay 20.95\u20ac/night for two people), the proximity to a historical village (willingness to pay 18.37\u20ac/night for two people) and, the location in a Natura 2000 SCI (willingness to pay 13.57\u20ac/night for two people). Furthermore, the results underline how the preservation of the traditional landscape and protection of the surrounding environment play a strategic role in developing agritourism and provide economic benefits to local communities

Social capital and rural innovation process. The evaluation of the measure 124 \u201cCooperation for Development of New Products, Processes and Technologies in the Agriculture, Food and Forestry Sector\u201d in the Umbria Region (Italy)

The most recent theories on innovation point out the role of social networks, demonstrating how knowledge is intertwined with network communities and social capital represents an essential factor to comprehend innovation. The social network dimension of the innovation process is also acknowledged in the actual definition of an agricultural innovation system (AIS). This study attempts to assess the role played by social capital in agricultural innovation projects co-financed by the Measure 124 of the Rural Development Program (2007-2013) of the Umbria Region (Italy), based on the analysis of 5 evaluation criteria (relevance, innovation, effectiveness, sustainability, and social capital) in relation to 8 selected projects. The obtained results confirm the validity of the proposed methodology both for the purpose of internal monitoring of the project and for the assessment of the measure on the basis of tangible and intangible factors, such as social capital

Le pacte agriurbain de la vallée ombrienne et les districts agricoles et culturels de Milan. Deux modèles de gestion des espaces agricoles périurbains

In peri-urban areas, the level of integration with the urban areas, the spatial organisation of the city and surroundings and the functions of agricultural system determine specific features of agricultural landscapes . The management of these areas is becoming increasingly important in order to guide the evolution orienteering the development in a perspective of spatial and functional integration. In Europe, some experiences of territorial planning as agricultural parks, agriurbain projects, agricultural districts, agriurbain pacts, pacts between city and countryside, are been developing. The success of these experiences, which often are expression of a new meaning of "rurality" are based on a strong participation and cohesion between the stakeholders thanks to practices of co-construction of space. The purpose of this paper is to present two experiments of co-construction of agriurbain territories : the agricultural and cultural district of Milan (Lombardia) and the agriurbain pact of Umbrian Valley (Umbria), analyzing the construction of the model, the intervention scales, the socio-economic actors involved and considering the role of policies implemented to manage these areas

Organizzazione e gestione dei servizi alle aziende della filiera carne bovina di qualità

Attualmente, il consumo della carne bovina di qualità standard, a causa dei ripetuti scandali alimentari e in particolare dei recenti casi di Bse (“Mucca pazza”) emersi anche nel nostro paese, è in calo. Viceversa, il consumo di carne bovina di qualità certificata è in crescita ma la filiera risulta debole e lo stadio di produzione potrebbe trovarsi impreparato a soddisfare la domanda. Da qui la necessità di pervenire, in breve tempo, a forme di coordinamento per l’erogazione di servizi destinati a favorire lo sviluppo degli accordi all’interno della filiera, in particolare di quelli relativi all’organizzazione commerciale dell’offerta, all’etichettatura del prodotto e alla garanzia della qualità della carne posta in vendita

Consumers demand for social farming products: An analysis with discrete choice experiments

This paper analyses the demand for social farming (SF) products. In particular, we investigate the preferences of consumers who buy their products from large retailers, rather than from solidarity purchasing groups or other niche markets using a sample of 225 consumers. In this regard, a discrete choice experiment (DCE) was carried out to estimate the willingness to pay (WTP) a premium price for the purchase of a common product (i.e., eggs) from farms that employ disabled people. The attributes considered in our DCE design are the employment of disabled people and two additional attributes which may have ethical implications for the choices. The results indicate that consumers are interested in buying SF products, with about 74% of the sample willing to buy the eggs produced by social farms and the average WTP being equal to \u20ac1.36 for a pack of six eggs. Moreover, the average WTP for the use of labour of disabled people attribute amounted to \u20ac0.69 for a pack of six eggs

Loss of runt-related transcription factor 3 expression leads hepatocellular carcinoma cells to escape apoptosis

Background: Runt-related transcription factor 3 (RUNX3) is known as a tumor suppressor gene for gastric cancer and other cancers, this gene may be involved in the development of hepatocellular carcinoma (HCC). Methods: RUNX3 expression was analyzed by immunoblot and immunohistochemistry in HCC cells and tissues, respectively. Hep3B cells, lacking endogenous RUNX3, were introduced with RUNX3 constructs. Cell proliferation was measured using the MTT assay and apoptosis was evaluated using DAPI staining. Apoptosis signaling was assessed by immunoblot analysis. Results: RUNX3 protein expression was frequently inactivated in the HCC cell lines (91%) and tissues (90%). RUNX3 expression inhibited 90 +/- 8% of cell growth at 72 h in serum starved Hep3B cells. Forty-eight hour serum starvation-induced apoptosis and the percentage of apoptotic cells reached 31 +/- 4% and 4 +/- 1% in RUNX3-expressing Hep3B and control cells, respectively. Apoptotic activity was increased by Bim expression and caspase-3 and caspase-9 activation. Conclusion: RUNX3 expression enhanced serum starvation-induced apoptosis in HCC cell lines. RUNX3 is deleted or weakly expressed in HCC, which leads to tumorigenesis by escaping apoptosis

Physical fitness in morbidly obese patients: effect of gastric bypass surgery and exercise training

Background There is a growing consensus that bariatric surgery is currently the most efficacious and long-term treatment for clinically severe obesity. However, it remains to be determined whether poor physical fitness, an important characteristic of these patients, improves as well. The purpose of this pilot study is to investigate the effect of gastric bypass surgery on physical fitness and to determine if an exercise program in the first 4 months is beneficial. Methods Fifteen morbidly obese patients (BMI 43.0 kg/m(2)) were tested before and 4 months after gastric bypass surgery. Eight of them followed a combined endurance and strength training program. Before and after 4 months the operation, anthropometrical characteristics were measured, and an extensive assessment of physical fitness (strength, aerobic, and functional capacity) was performed. Results Large-scale weight loss through gastric bypass surgery results in a decrease in dynamic and static muscle strength and no improvement of aerobic capacity. In contrast, an intensive exercise program could prevent the decrease and even induced an increase in strength of most muscle groups. Together with an improvement in aerobic capacity, functional capacity increased significantly. Both groups evolved equally with regard to body composition (decrease in fat mass and fat-free mass). Conclusions An exercise training program in the first 4 months after bariatric surgery is effective and should be promoted, considering the fact that physical fitness does not improve by weight loss only

A Controversy That Has Been Tough to Swallow: Is the Treatment of Achalasia Now Digested?

Esophageal achalasia is a rare neurodegenerative disease of the esophagus and the lower esophageal sphincter that presents within a spectrum of disease severity related to progressive pathological changes, most commonly resulting in dysphagia. The pathophysiology of achalasia is still incompletely understood, but recent evidence suggests that degeneration of the postganglionic inhibitory nerves of the myenteric plexus could be due to an infectious or autoimmune mechanism, and nitric oxide is the neurotransmitter affected. Current treatment of achalasia is directed at palliation of symptoms. Therapies include pharmacological therapy, endoscopic injection of botulinum toxin, endoscopic dilation, and surgery. Until the late 1980s, endoscopic dilation was the first line of therapy. The advent of safe and effective minimally invasive surgical techniques in the early 1990s paved the way for the introduction of laparoscopic myotomy. This review will discuss the most up-to-date information regarding the pathophysiology, diagnosis, and treatment of achalasia, including a historical perspective. The laparoscopic Heller myotomy with partial fundoplication performed at an experienced center is currently the first line of therapy because it offers a low complication rate, the most durable symptom relief, and the lowest incidence of postoperative gastroesophageal reflux

Mortality and pulmonary complications in patients undergoing surgery with perioperative sars-cov-2 infection: An international cohort study

Background The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (740%) had emergency surgery and 280 (248%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (261%) patients. 30-day mortality was 238% (268 of 1128). Pulmonary complications occurred in 577 (512%) of 1128 patients; 30-day mortality in these patients was 380% (219 of 577), accounting for 817% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 175 [95% CI 128-240], p<00001), age 70 years or older versus younger than 70 years (230 [165-322], p<00001), American Society of Anesthesiologists grades 3-5 versus grades 1-2 (235 [157-353], p<00001), malignant versus benign or obstetric diagnosis (155 [101-239], p=0046), emergency versus elective surgery (167 [106-263], p=0026), and major versus minor surgery (152 [101-231], p=0047). Interpretation Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research